Michael Grasso - Research


Research Interests

We are conducting research into innovative applications of biomedical informatics that expand the scope of clinical medicine, have a strong theoretical basis in computer science, and are of strategic importance to the University of Maryland Medical System. We are developing new approaches to knowledge representation and reasoning, which are optimized for very large clinical repositories, and which can be applied to disease prediction, critical event prediction, and treatment efficacy prediction. The clinical focus for this work includes several chronic diseases, opioid misuse and addiction, quality improvement in Emergency Medicine, opioid prescribing practices, and online consumer health information.

Current Research Projects

  • Knowledge Representation and Reasoning with Big Data - We are developing new methods for knowledge representation and reasoning that are optimized for very large clinical repositories, and which can be correlated with genomic and environmental data. Our specific approach is to enhance machine learning algorithms with semantic analysis, domain information, and deep learning. Our clinical focus is on coronary artery disease, diabetes, rheumatoid arthritis, chronic kidney disease, chronic pain, addiction, and mental illness. This work may lead to new approaches for disease prediction, critical event prediction, and treatment efficacy prediction. We are currently working with the national clinical repository from the Veterans Health Administration, which contains data on more than 35 million patients from roughly 150 medical centers and 800 outpatient clinics, as well as the EPIC clinical repository from the 14 member hospitals within the University of Maryland Medical System and the Maryland Emergency Medicine Network.

  • Patient Safety and Quality Measures in Emergency Medicine - Patient safety and quality is one of the nation's most important health care challenges. This is especially important in the emergency department, where health care teams are challenged to rapidly diagnose and treat multiple patients, some of whom present with potentially life-threatening illness. We are conducting research in resource utilization and recidivism in emergency medicine, with a focus on co-morbidities, key risk factors, adverse drug events, chronic pain, suicidality, addiction, utilization patterns, clinical workflow, SARS-CoV-2, opioid prescribing practices, and consumer health information.

  • Online Consumer Health Information - We know from prior studies that roughly one third of people search the internet for consumer health information before presenting to an emergency department for acute care, and that 75% of those searches contain inaccurate information. We are conducting research to examine the impact of these consumer health searches on the provision of patient care, with a focus on mismatched patient-physician expectations and changes in established practice guidelines.

Students

  • Students who are enrolled at the University of Maryland (UMB, UMBC, UMD, etc.) may contact me about research opportunities. Unfortunately, we can not engage staff, students, or volunteers who are not already enrolled or working within the University of Maryland System.

Publications

Graduate Students

  • Miguel Ossandon, 2009, PhD Student, visual sensory substitution
  • Xianshu Zhu, 2009, MS Student, clinical image processing
  • Dashana Dalvi, 2009-2010, MS Student, clinical image processing
  • David Chapman, 2010, PhD Student, clinical image processing with semantic metadata in cell biology
  • Justin martineua, 2010-2011, PhD Student, clinical image processing with semantic metadata in cell biology
  • Ronil Mokashi, 2009-2011, MS Student, clinical image processing with semantic metadata in cell biology
  • Ashwini Lahane, 2010-2011, MS Student, Thesis Committee, clinical image processing
  • Ronil Mokashi, 2011, MS Student, Thesis Committee, clinical image processing
  • Dashana Dalvi, 2011, MS Student, Thesis Committee, genomic prediction of type 2 diabetes
  • Aniket Bochare, 2011-2012, MS Student, Thesis Committee, domain knowledge and genomic prediction
  • Ronil Mokashi, 2011-2012, MS Student, Thesis Committee, genomic association and machine learning
  • Zachary Kurtz, 2012, MS Student, Thesis Committee, simultaneous feature and cost estimation
  • Eduardo Llamas, 2012, MS Student, Thesis Committee, extraction of drug-gene relationships
  • Soma Das, 2011-2012, MS Student, Thesis Advisor, genomic prediction of coronary artery disease
  • Matthew Gately, 2011-2012, MS Student, Thesis Advisor, personalized medicine
  • Isaac Mativo, 2012-2016, PhD Student, Thesis Advisor, predictive models for clinical decision support
  • Christopher Chen, 2013, SRTP Summer Medical Student, genomic prediction of diabetes using biological enrichment
  • Sandeep Regmi, 2014, Medical Resident, wearable computing for clinical decision support
  • Matthew Lotz, 2015, PRISM Summer Medical Student, genomic prediction of coronary artery disease using biological enrichment
  • Rose Yesha, 2016, PhD Student, Thesis Committee, automated methods for analyzing unstructured medical data
  • Phil Magidson, 2016-2018, Emergency Medicine Resident, clinical informatics
  • Jay Gholap, 2018, PhD Student, Research Mentor, phenotype analytics applied to osteoarthritis
  • Mohammad Alodadi, 2018-2020, PhD Student, Dissertation Committee, knowledge discovery in clinical notes
  • Benjamin Nosrati, 2019-2020, Medical Student, online consumer health information
  • Zachary Kim, 2019-2020, Medical Student, online consumer health information
  • Alexandra Rogalski, 2019-2021, Medical Student, online consumer health information

Past Research Projects

  • Syndromic surveillance for bioterorism and medical disasters.
  • A computerized approach to glycemic control.
  • Identification and analysis of TSH-assoicated SNPs.
  • Assocation between ventricular assist devices and gastrointestinal bleeding.
  • Efforts to minimize adverse events by cross-covering physicians.
  • Medical response to terrorist attacks and other disasters.
  • Clinical trials data collection using handheld computers.
  • Voice-driven clinical data collection.
  • Computational image classification.
  • Intelligent software agents for disaster management.

Additional Links

Personal

Clinical Informatics

Emergency Medicine

Internal Medicine

References/Libraries

Music